Originally built in c.1860, the Avondale Railway Station was part of a flourishing railroad network which spread across the U.S. throughout the 19th century.  Avondale was home to two separate rail lines, the Pomeroy and Newark (which later became part of the Pennsylvania RR) and the Philadelphia & Baltimore Central Railroad.  The stone building that remains on the property today serviced as both a passenger and freight building.

While the exact history of the structure is rather unclear, a series of modifications over the years led it to go from a two story building with adjoining support structures to a one story structure with a different roof line.  The second story was removed in the mid 1940’s during a refurbishment of the building as well as the removal of the overhangs and support brackets.  A door way and several windows along the front facade were also removed at this time.